August 16, 2022

It has been one of the crucial enduring Covid conspiracy theories: that the ‘gold commonplace’ PCR checks used to diagnose the virus had been choosing up individuals who weren’t really contaminated.

Some even urged the swabs, which have been carried out greater than 200 million occasions within the UK alone, could mistake frequent colds and flu for corona.

If both, or each, had been true, it will imply many of those circumstances ought to by no means have been counted within the each day tally – that the ominous and all-too-familiar determine, which was used to tell selections on lockdowns and different pandemic measures, was an over-count.

And lots of of those that had been ‘pinged’ and compelled to isolate as a contact of somebody who examined optimistic – inflicting an enormous pressure on the financial system – did so unnecessarily.

Such statements, it have to be stated, have been roundly dismissed by prime specialists. And people scientists keen to offer credence such issues have been shouted down on social media, accused of being ‘Covid-deniers’, and even sidelined by colleagues.

However might they’ve been proper all alongside?

Right this moment, within the first a part of a significant new sequence, The Mail on Sunday investigates whether or not ‘the science’ that The Authorities so usually stated they had been following through the pandemic was flawed, a minimum of in some respects.

Within the coming weeks we are going to look at if Britain’s stark Covid loss of life determine was overblown. We will even ask if lockdowns did extra hurt than good.


Have been the pandemic an infection figures intentionally ‘sexed up’ to scare folks in complying with lockdown guidelines? 

However this week, we deal with the talk round Covid checks, and look at whether or not there may be any fact to the claims that they had been by no means match for objective.

Final month a report by the analysis charity Collateral International and lecturers at Oxford College concluded as a lot, stating that as many as one third of all optimistic circumstances could not have been infectious.

If they’re proper, that’s a probably staggering quantity – roughly six million circumstances.

The Oxford scientists branded the UK’s testing programme – which value an eye-watering £2bn-a-month – as ‘chaotic and wasteful’.

It’s, say these critics, not merely necessary that we study from our errors.

For whereas testing will now solely be routine supplied to sufferers after they come into hospitals, or in different medical settings, and to the weak, PCRs will nonetheless be used to trace the unfold of the virus in the neighborhood. And may there be a resurgence, that quantity will as soon as once more inform coverage.

Right this moment, within the first a part of a significant new sequence, The Mail on Sunday investigates whether or not ‘the science’ that The Authorities so usually stated they had been following through the pandemic was flawed, a minimum of in some respects. Pictured: Professor Chris Whitty, Boris Johnson and former Well being Secretary Matt Hancock at a Coronavirus press briefing

It has been one of the most enduring Covid conspiracy theories: that the 'gold standard' PCR tests used to diagnose the virus were picking up people who weren't actually infected (stock photo)

It has been one of the crucial enduring Covid conspiracy theories: that the ‘gold commonplace’ PCR checks used to diagnose the virus had been choosing up individuals who weren’t really contaminated (inventory photograph)

Practically two years on from the primary lockdown, how positive can we be that circumstances weren’t, as some have argued, overstated?

As ever with something Covid-related, it’s a posh and nuanced image, and there may be removed from a consensus on this level.

Collateral International’s determine has been disputed, and different scientists say that if non-infectious positives did distort case numbers, it was by a minimal quantity. Others dismiss any notion that testing performed something aside from a significant function in our combat towards Covid.

However as Professor Francois Balloux, director of College Faculty London’s Genetics Institute, instructed The Mail on Sunday: ‘Many individuals could not have been infectious, regardless of getting a optimistic check.’

Key to understanding the difficulty lies in how PCR checks work and the Authorities selections that dictated how they had been used.

PCRs detect tiny fragments of Covid genes, often known as RNA, in samples taken from the nostril and throat. To do that, swabs are handled in a lab with chemical substances to extract the genetic materials.

There may be such a tiny quantity of RNA on the swabs that it needs to be amplified in a machine earlier than it may be detected. That is performed by repeating a cycle of heating and cooling, which inspires the genetic materials to make copies of itself.

The extra occasions the cycle is carried out, the extra copies are made and the extra seemingly it’s the machine will detect the virus.

This method has been used efficiently for non-Covid viruses, reminiscent of HIV and hepatitis, and in crime scene forensics when in search of DNA. It’s superb at figuring out whether or not minuscule quantities of genetic code are there or not.

However relating to Covid, there’s a downside. The very small quantities might both be from a dwell virus – which implies somebody is probably infectious – or useless fragments left over from a beforehand cleared an infection.

And these useless fragments can linger for as much as 90 days, in response to research.


The UK spent greater than £2 billion on Covid testing in January alone, in response to Prime Minister Boris Johnson.

Consultants additionally say some individuals who bought Covid however had been asymptomatic or barely affected – and, the proof reveals, much less prone to transmit it – may also check optimistic and must isolate.

One other concern lies in how the PCR checks had been carried out.

At the beginning of the pandemic, when solely NHS workers and people admitted to hospital had been being examined, the hospitals and a choose few laboratories run by the now-disbanded Public Well being England had been processing them.

In early April 2020, the Authorities introduced that it needed to carry out 100,000 checks a day, and farmed out the work to its newly established community of Lighthouse Labs.

Dubbed ‘Covid mega-labs’, as every had the capability to course of upward of fifty,000 swabs a day, they had been run by the Division of Well being and Social Care in partnership with monetary agency Deloitte, bringing on board lecturers.

Professor Alan McNally, a College of Birmingham microbiologist who helped arrange the Lighthouse Lab in Milton Keynes, stated the choice meant PCR testing strategies had been ‘largely standardised’.

The labs carried out 90 per cent of PCR testing for many of 2020, with the remaining ten per cent carried out by NHS trusts on workers and sufferers.

However the issues got here in early 2021, when testing was scaled up additional and extra was farmed out to the non-public sector.

‘There seems to have been little or no oversight of those new labs, and with completely different PCR strategies and tools getting used,’ says Prof McNally.

‘In Milton Keynes, each check we carried out was scrutinised and checked by specialists, the standard was poured over daily and we had been held to account.

‘Clearly in a number of the newer labs, that didn’t occur. Cynically, one would possibly say it virtually became a money-making train for the non-public sector as we had lateral flows by then and everybody knew how do them.

‘Why did we want costly PCRs? The check outcomes principally grew to become meaningless.’

The Immensa labs scandal, in late 2021, was the most important casualty of this determination. It was found the Wolverhampton lab had given 43,000 folks adverse outcomes when, in actual fact, that they had Covid.

It led to a pointy rise in circumstances within the South West of England. But it surely’s unlikely to have been the one instance.

‘I’ve been contacted a few occasions about different examples,’ says Prof McNally. ‘There’ll all the time be errors in labs, often they’re caught rapidly. Immensa was solely the worst one.’

In early April 2020, the Government announced that it wanted to perform 100,000 tests a day, and farmed out the work to its newly established network of Lighthouse Labs (stock photo)

In early April 2020, the Authorities introduced that it needed to carry out 100,000 checks a day, and farmed out the work to its newly established community of Lighthouse Labs (inventory photograph)

The Collateral International report discovered there have been large variations within the strategies getting used to conduct PCR checks at labs throughout the nation.

It analysed greater than 300 Freedom of Info requests and located there have been 80 to 85 various kinds of testing machines in use.

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Every have to be used in response to the producer’s directions, which suggest what number of cycles of amplification needs to be performed earlier than a check is taken into account optimistic.

In some circumstances it was as little as 25 cycles, in others as many as 45. Some specialists argue this is a vital distinction.

If somebody checks optimistic at a low cycle threshold they’re prone to have quite a lot of viral fragments current of their pattern – as a result of it doesn’t must be amplified too many occasions to be detected – and really seemingly infectious.

The reverse can also be true – a excessive cycle threshold can imply a optimistic outcome even when little or no virus is current within the unique pattern.

The fear is that if some machines are operating extra cycles, they’ll choosing up extra ‘positives’ than others – and that a lot of these gained’t be infectious, or ‘dwell’ circumstances.

Dr Tom Jefferson, who led the evaluation, believes 30 cycles is an effective cut-off.


On January 6, there have been greater than 698,000 PCR checks carried in England – essentially the most recorded in a single day, in response to Authorities figures.

Nonetheless the report discovered about one third of optimistic PCR ends in some labs had undergone greater than that this variety of cycles.

Dr Jefferson claims this implies these people who had been subsequently instructed that they had Covid had been no hazard to anybody.

‘Covid press conferences had been all about circumstances, hospital admissions and making comparisons with different nations,’ Dr Jefferson stated.

‘In actuality, comparisons even between hospital trusts could also be tough as a result of the outcomes will depend on what check you employ, what machine, what chemical substances.

‘The explanation we needed to spend billions figuring out infectious circumstances was to cease or delay transmission. What the Authorities really did was roll out checks on an industrial scale and located large numbers of positives – which is hardly stunning if some are being run via 45 cycles.’

Different scientists reject Dr Jefferson’s argument. Amongst them is Professor Richard Tedder, a former virologist for Public Well being England who helped pioneer PCR checks. He says specializing in cycle thresholds is ‘absolute stupidity’.

He says some machines have to carry out extra cycles than others to detect the identical viral fragments, and this will depend on plenty of components together with which chemical substances are used, how the genetic materials is extracted from the swab and the way diluted the pattern is. It means you can’t examine – or standardise – cycle thresholds.

PCR checks additionally must be delicate to choose up early-stage infections, when the quantity of virus in a swab is likely to be low – however prone to improve, making folks extra infectious.

This was a vital device for combating the foremost problem initially of the pandemic – recognizing the virus and isolating sufferers earlier than it might unfold.

‘Plenty of swabs which solely go optimistic after 35 cycles are completely actual infections,’ Prof Tedder argues.

‘By some strategies, the affected person can be instructed they’re adverse. But they could have been incubating the an infection, and in the event you sampled them once more two days later their check would go optimistic after solely 25 cycles.

‘You can’t due to this fact dismiss the samples that solely present a optimistic outcome after 35 cycles. To say you may’t use these check outcomes is errant nonsense and harmful – we have to destroy this damned fantasy.’

Dr Alexander Edwards, affiliate professor in biomedical know-how on the College of Studying, acknowledges PCR checks ‘aren’t excellent’ however provides: ‘Sure, it might decide up tiny quantities of virus, however those that say which means it isn’t sufficient to be infectious are lacking the purpose.

‘In case you don’t [make the test highly sensitive and] decide up these tiny quantities you’ll miss individuals who occur to not get quite a lot of virus on their swab.

‘You possibly can speak all you want about Machine A being extra delicate than Machine B, however the fact is each time you place a swab up folks’s noses you get a variable quantity of virus.

‘And for the overwhelming majority of people that check optimistic, their swabs will flip optimistic after solely a small variety of cycles – so it doesn’t matter what machine you employ.’

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Dr Edwards admits there shall be ‘small variations’ within the variety of positives relying on the machine.

‘In case you have a machine which is ten occasions extra delicate at choosing up virus, you’ll decide up about 5 to 10 per cent extra folks.’

The million-dollar query is whether or not those that check optimistic after a excessive cycle threshold are infectious – and there’s no consensus on this, Dr Edwards says.

‘The argument about cycle thresholds and infectiousness is an unlucky distraction,’ he provides.

‘The bulk of people that check optimistic on a PCR, regardless of what number of cycles it has been via, are prone to be infectious. One of the best you are able to do is use a optimistic check as a pink flag for seemingly infectiousness and ask folks to remain inside.’

Regardless of this, a rising variety of specialists now say that PCR testing might have been scrapped fully in early 2021 because the vaccines had been rolled out.

They are saying it was badly wanted in 2020 to get a deal with on hovering Covid deaths and cease folks unknowingly passing on the virus, however by final summer time, with the bulk vaccinated, it was ‘pointless’.

Professor Allyson Pollock, medical professor of public well being at Newcastle College, argues that rolling out PCRs to larger numbers of individuals was ‘one of many largest errors’ of the UK’s pandemic response.

Testing on such an unlimited scale made it inconceivable to know what quantity of swabs had really simply picked up useless virus fragments, she argues.

Some folks could have sought a PCR check after creating signs that had been because of the frequent chilly.

However PCR checks could have picked up fragments of Covid from a previous an infection, leading to a optimistic outcome and pointless isolation.

‘We might have scrapped PCR altogether and this may need averted the pingdemic, when thousands and thousands of individuals had been instructed to remain at residence after being in touch with a optimistic case,’ Prof Pollock says.

She factors to the conclusion of a Public Accounts Committee report, printed in October, which acknowledged that all the Check & Hint system had little impact on the unfold of Covid.

‘We wasted billions,’ she says. ‘In the meantime, faculties, transport and well being companies had been closed or suspended and other people had been stopped from seeing their kin in care houses and hospitals.’

Prof McNally agrees testing might have been scaled again earlier.

‘As soon as we began to vaccinate and gave everybody entry to lateral circulation checks, you would have stopped reporting case numbers from PCR checks,’ he says. ‘It’s exhausting to see how we justified persevering with mass PCR testing in 2021.’

However as a supply near the Authorities’s testing technique explains: ‘The explanation we continued PCR testing final 12 months is as a result of long-term contracts had already been signed with the labs and the cash had modified fingers. The Authorities couldn’t do something about it.

‘It’s no coincidence PCR testing [for the general population] is ending on March 31 – that’s when the contracts finish.’

So what has the affect of all this testing been? Have been circumstances numbers actually overstated? The reply is, undoubtedly, sure. But it surely’s exhausting to inform precisely by how a lot.

Every one who checks optimistic can have been contaminated by Covid sooner or later, which is why traces of the virus’s RNA had been detected.

And there may be some proof our Covid whole could even have been underestimated.

A report into NHS Check & Hint discovered solely a minority of individuals with Covid signs – between 18 and 33 per cent – bought examined.

Different analysis monitoring Covid infections, together with the Workplace for Nationwide Statistics survey, which is extensively thought-about to be essentially the most correct of the varied case monitoring research, additionally suggests the quantity of people that had Covid at anyone time typically tallied with the Authorities’s each day totals.

The plain counter to that is that everybody concerned within the survey is screened weekly… utilizing a PCR. However the level on which most specialists now agree is that this: the tip of mass Covid testing is lengthy overdue.